Innovative Techniques for Complex Meniscal Repair, Substitution, and Meniscal Allograft Transplantation (AANA19)-Innovative Techniques for Augmentation Of Meniscus Healing-Dr. Scott A. Rodeo, M.D.

Innovative Techniques for Augmentation Of Meniscus Healing-Dr. Scott A. Rodeo, M.D.

Video Transcription

Video Summary

The video discusses meniscus repair challenges and biologic augmentation strategies. Preserving the meniscus is crucial, but healing is slow and influenced by factors like vascularity, cell presence, inflammation, and mechanical load. Surgeons should selectively repair tears with healing potential, as failure rates can be high and rehab lengthy. Current augmentation techniques include synovial abrasion, fibrin clots, marrow venting (microfracture), platelet-rich plasma (PRP), and cell-based therapies using bone marrow or adipose-derived cells. Data on PRP and cell therapies are mixed and limited, with variability in formulations and regulatory constraints limiting use of true stem cells. Stimulating intrinsic progenitor cells in meniscus and synovium shows promise. Modulating the joint's inflammatory environment—targeting mediators like IL-1 and MMPs—and using scaffolds, adhesives, and physical modalities (e.g., ultrasound) may enhance healing. Future advances likely involve combining scaffolds, cells, and signals, focusing on intrinsic stem cell niches and intra-articular environment modulation to improve meniscus repair outcomes.

Asset Caption

Instructional Course Lecture: Innovative Techniques for Complex Meniscal Repair, Substitution, and Meniscal Allograft Transplantation

Keywords

meniscus repair

biologic augmentation

platelet-rich plasma

cell-based therapies

inflammatory modulation

scaffold and adhesive techniques