Hype, Promise, and Reality Orthopedic Use of Biologics (2021 Annual Meeting)-Hype, Promise, and Reality_ Orthopedic Use of Biologics in 2021'-Rodeo

Video Transcription

Video Summary

The speaker provides an in-depth overview of orthobiologics and regenerative medicine, focusing on current potentials and limitations, particularly in tendinopathy treatment. They emphasize the misuse of the term "stem cells," advocating for more precise terminology like "connective tissue progenitor cells" due to the heterogeneity and minimal manipulation of cell preparations. Various sources of cells—bone marrow, adipose, perinatal tissues—and their processing methods are discussed, highlighting regulatory constraints and inconsistent clinical data. Platelet-rich plasma (PRP), especially leukocyte-rich formulations, show promise in symptom modification for tendons but limited evidence of structural regeneration; optimal PRP use remains unclear due to variability in products and formulations. For rotator cuff repair, PRP may improve structural healing; cell therapy shows potential but requires further study. The speaker stresses the need for standardized product characterization, a personalized medicine approach targeting specific biological mechanisms, and caution against indiscriminate marketing of unproven therapies. They advocate exercise leadership and continued rigorous research to responsibly advance this evolving field.

Asset Caption

Dr. Scott A. Rodeo

Keywords

orthobiologics

regenerative medicine

tendinopathy treatment

connective tissue progenitor cells

platelet-rich plasma

rotator cuff repair