Hype, Promise, and Reality Orthopedic Use of Biologics (2021 Annual Meeting)-Hype, Promise, and Reality_ Orthopedic Use of Biologics in 2021'-Dragoo

Hype, Promise, and Reality_ Orthopedic Use of Biologics in 2021'-Dragoo

Video Transcription

Video Summary

This talk addresses the evolving field of regenerative medicine, focusing on cellular therapies for cartilage repair. The FDA has recently cracked down on unregulated stem cell products, leading to a shift from the term "stem cell therapy" to "cellular therapy," reflecting the use of progenitor cells rather than true stem cells. Evidence shows cellular therapies, mainly bone marrow aspirate concentrate (BMAC) and adipose-derived cells, provide pain relief and anti-inflammatory effects through immunomodulation, with emerging data suggesting potential cartilage regeneration. Bone marrow harvesting technique is crucial for maximizing cell yield, while adipose tissue requires specialized processing. Clinical data indicate adipose-derived cells improve pain and function in osteoarthritis, with some MRI evidence of cartilage thickening, whereas BMAC shows limited osteoarthritis benefit but promise in cartilage defects. Juvenile chondrocytes offer another avenue due to their enhanced regenerative potential. Caution is advised regarding allografts and amniotic products due to safety and efficacy concerns. New approaches also target subchondral bone remodeling to support cartilage health, highlighting this field's early but promising state.

Asset Caption

Dr. Jason L. Dragoo

Keywords

regenerative medicine

cellular therapy

cartilage repair

bone marrow aspirate concentrate

adipose-derived cells

osteoarthritis