Diagnosis and Management of Patellofemoral Cartilage Injuries (2023 Annual Meeting)-Cell-Based Cartilage Restoration of the PF Joint

Cell-Based Cartilage Restoration of the PF Joint

Video Transcription

Video Summary

The video discusses treating symptomatic chondral lesions of the patella using cell-based therapies. Articular cartilage lesions are common, especially in athletes and older individuals, leading to osteoarthritis if untreated. Cartilage’s avascular nature limits healing; deeper injuries trigger scar formation, not true cartilage regeneration. Treatments include autologous chondrocyte implantation (ACI), showing durable outcomes over 10+ years, and mesenchymal stem cells (MSCs), though their long-term efficacy is less established. Microfracture offers short-term relief but deteriorates over time. Combining cell therapy with osteotomies for malalignment may improve results. Emerging arthroscopic and allograft cell-based products show promise. Overall, cell-based therapy offers a durable solution for patellar chondral defects.

Asset Caption

Cassandra Lee, M.D.

Keywords

patellar chondral lesions

cell-based therapy

autologous chondrocyte implantation

mesenchymal stem cells

osteoarthritis treatment