Course Lecture Pearls: Advanced Knee-Articular Cartilage-Orthobiologics Injections in the Knee (BMAC, Amniotic, Fat)_ What’s Appropriate Based on the Evidence_-Faculty Lecture

Orthobiologics Injections in the Knee (BMAC, Amniotic, Fat)_ What’s Appropriate Based on the Evidence_-Faculty Lecture_ Brian Chilelli, MD

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Video Transcription

Video Summary

The presentation discusses orthobiologics, focusing on stem cell therapies and cellular treatments for degenerative joint conditions. True stem cell therapies involve cultured, expanded cells with specific regenerative abilities, while many treatments labeled "stem cells" are actually heterogeneous cell concentrates like bone marrow aspirate concentrate (BMAC) or adipose-derived products, which contain few stem cells. The FDA restricts manipulation and culture expansion of cells, limiting available treatments. Studies show mixed results, with few robust randomized controlled trials. Amniotic fluid products do not contain viable stem cells despite claims. The speaker emphasizes cautious interpretation of terminology and calls for better patient education and more rigorous research in orthobiologics.

Keywords

orthobiologics

stem cell therapies

degenerative joint conditions

bone marrow aspirate concentrate

FDA regulations