AANA19 Knee Access Pass-Synthetic Plugs is the Way of Future - Featured Lecture-Dr. John M. O'Byrne, M.D.

Synthetic Plugs is the Way of Future - Featured Lecture-Dr. John M. O'Byrne, M.D.

Video Transcription

Video Summary

The speaker discusses tissue engineering research in Dublin focused on cartilage and bone repair. They highlight challenges with donor tissue shortages and present their work on collagen-based scaffolds tested in animals and humans. A novel osteochondral plug combining collagen types and pore sizes has shown promising results, including restoring function in a show-jumping horse. Further advancements involve stem cells, gene-activated scaffolds, and nanoparticles to enhance tissue regeneration safely. Recently, 3D printing has been integrated to optimize scaffold structure and mechanical properties. This multifaceted approach aims to develop metabolically active, functional cartilage implants for patients. The speaker thanks the audience and acknowledges collaborative efforts.

Keywords

tissue engineering

collagen scaffolds

osteochondral plug

3D printing

stem cell therapy