AANA19 Knee Access Pass-Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss, M.D.

Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss, M.D.

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Video Summary

This pilot study examined synovial fluid biomarkers in 16 ACL rupture patients between injury and surgery, revealing significant changes in eight of ten markers. Notably, pro-inflammatory Rantes and FGF increased, while IL-6, MCP-1, VEGF, TIMP2, and IL-1 receptor antagonist decreased. These biomarker shifts reflect ongoing intraarticular inflammation and tissue response. Elevated IL-6, linked to cartilage damage and post-traumatic osteoarthritis, may guide optimal surgery timing and targeted therapies. Although limited by sample size and time points, this research highlights the joint microenvironment's role post-ACL injury and aims to improve individualized treatments to reduce long-term osteoarthritis risk.

Keywords

ACL rupture

synovial fluid biomarkers

intraarticular inflammation

IL-6

post-traumatic osteoarthritis