AANA19 Foot & Ankle Access Pass-Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss

Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss

Back to course

Video Transcription

Video Summary

This pilot study examined changes in synovial fluid biomarkers between ACL injury and reconstruction surgery, analyzing samples from 16 patients at injury and pre-surgery. Results showed significant alterations in eight out of ten biomarkers, including increased pro-inflammatory RANTES and decreased interleukin-6 (IL-6) levels over time. Elevated IL-6 is linked to cartilage degradation and post-traumatic osteoarthritis, suggesting its potential as a marker for optimal surgery timing and treatment target. Although limited by sample size and timing, the study highlights ongoing joint microenvironment changes post-ACL rupture, aiming to improve personalized treatments and reduce arthritis risk.

Keywords

ACL injury

synovial fluid biomarkers

interleukin-6

RANTES

post-traumatic osteoarthritis