2023 Specialty Day Access Pass-The New/Emerging Blood-Based Formulations Beyond PRP

The New/Emerging Blood-Based Formulations Beyond PRP

Video Transcription

Video Summary

Nick Puisi discusses the evolution and challenges of platelet-rich plasma (PRP) therapy in orthopedics. Despite PRP's 70-year history and growing use, its preparation methods remain mostly unchanged, with limited understanding of its precise composition and mechanisms in vivo. Current PRP lacks standardized protocols, quality controls, and clear patient-selection criteria. Future advances may involve isolating and utilizing exosomes for targeted therapies, enabling better disease mechanism targeting and patient phenotyping. However, these developments are early-stage and clinical application will take time. Optimizing existing PRP use by identifying responders may be more immediately impactful than awaiting novel treatments.

Asset Caption

Nicolas Piuzzi, M.D.

Keywords

platelet-rich plasma

PRP therapy

orthopedics

exosomes

patient phenotyping