2023 Specialty Day Access Pass-Biologics Is More Than Just PRP and Bone Marrow: Scaffolds, Cytokines, Pharmacologic Agents

Biologics Is More Than Just PRP and Bone Marrow: Scaffolds, Cytokines, Pharmacologic Agents

Video Transcription

Video Summary

Scott Rodeo discusses expanding orthobiologics beyond PRP and cell therapies, focusing on scaffold cytokines, pharmacologic agents, and physical modalities to improve soft tissue healing. He highlights two osteoinductive cytokines—PDGF and BMP-2—used off-label for soft tissue-to-bone repair, and emerging cytokines like TGF-beta-3 and connective tissue growth factor. Scaffold materials, including patches and cell sheets, support tissue regeneration. Repurposing approved drugs—like parathyroid hormone, statins, IL-17 inhibitors, and metformin—shows promise in enhancing soft tissue and cartilage healing. Rodeo emphasizes understanding molecular mechanisms and pathology to tailor personalized, potentially combined orthobiologic therapies for optimal patient outcomes.

Asset Caption

Scott A. Rodeo, M.D.

Keywords

orthobiologics

cytokines

soft tissue healing

scaffold materials

pharmacologic agents