2023 Specialty Day Access Pass-ACL Reconstruction and Repair: What Is the Role for Biologics?

ACL Reconstruction and Repair: What Is the Role for Biologics?

Video Transcription

Video Summary

The presentation discussed the use of orthobiologics, especially platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and mesenchymal stem cells (MSCs), to enhance ACL reconstruction outcomes. PRP showed short-term improvements in pain and function but lacked long-term clinical benefits or improved knee stability. PRF showed promise in graft integration and reducing post-op hemarthrosis but did not improve graft survival rates. MSCs may reduce joint degeneration post-ACL surgery yet lack data on ligament healing. Scaffold-enhanced ACL repair demonstrated comparable outcomes to traditional reconstruction with better hamstring strength. Overall, despite potential benefits, inconsistent preparation and limited evidence demand more standardized, controlled studies for orthobiologic effectiveness in ACL treatment.

Asset Caption

Leah C. Brown, M.D.

Keywords

orthobiologics

ACL reconstruction

platelet-rich plasma

mesenchymal stem cells

scaffold-enhanced repair