2023 Annual Meeting Biologics-Lesion Features Have No Effect on Outcomes When Comparing a Coral Scaffold vs. Debridement

Lesion Features Have No Effect on Outcomes When Comparing a Coral Scaffold vs. Debridement_Microfixation

Video Transcription

Video Summary

This presentation discussed a novel biphasic cartilage scaffold made of aragonite coral, designed to promote true hyaline cartilage regeneration for treating knee lesions, including mild to moderate osteoarthritis (KL 0-3). The scaffold’s top layer has proprietary drill holes stimulating chondrogenesis, while the rest supports bone healing. A large, multicenter U.S. phase 3 trial showed significant improvements over standard treatments (microfracture/debridement) in knee function scores, MRI defect fill, and low failure rates. The scaffold is cost-effective (~$5,000), cell-free, and suitable for various lesion sizes and types, with anticipated U.S. availability mid-2024.

Asset Caption

Kenneth R. Zaslav, M.D.

Keywords

biphasic cartilage scaffold

aragonite coral

hyaline cartilage regeneration

knee osteoarthritis treatment

phase 3 clinical trial