2021 Annual Meeting Startup & Practice Management Access Pass-In-Vitro Analysis of Acute Interventions for Post-Traumatic Osteoarthritis

In-Vitro Analysis of Acute Interventions for Post-Traumatic Osteoarthritis

Video Transcription

Video Summary

Dr. Adam Yankee from Rush University discusses his research on post-traumatic osteoarthritis (PTOA) and potential treatments. PTOA results from inflammation after joint injuries, leading to cartilage breakdown. Their lab uses a controlled human cartilage and synovium co-culture model to study therapies like amniotic suspension allograft (ASA) and dehydrated IL-1 receptor antagonist protein (IRAP), aiming to mitigate inflammatory cascades. ASA shows promising anti-inflammatory effects in vitro, unlike bone marrow concentrate. They plan to measure cytokine changes and gene expression over 14 days post-injury. The study could inform future clinical trials targeting early intervention to reduce PTOA progression and healthcare costs.

Asset Caption

Dr. Adam Yanke

Keywords

post-traumatic osteoarthritis

inflammation

amniotic suspension allograft

IL-1 receptor antagonist protein

cartilage co-culture model