2021 Annual Meeting Knee Access Pass-The beneficial effect of intra-articular injection of losartan on the microfracture mediated cartilage repair is dose dependent

The beneficial effect of intra-articular injection of losartan on the microfracture mediated cartilage repair is dose dependent

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This study investigated the effects of intra-articular lisartan injections on cartilage healing after microfracture in rabbits. Low doses (0.1, 1, and 10 mg) enhanced hyaline-like cartilage repair and improved cell distribution, while a high dose (100 mg) was detrimental, impairing healing and damaging surrounding tissue. The findings suggest low-dose intra-articular lisartan may improve cartilage repair, aligning with prior oral lisartan uses to reduce fibrosis. However, the study was short-term, limited to rabbits, and requires further research in larger animals before clinical application. This novel approach aims to enhance cartilage healing while minimizing systemic side effects.

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Dr. Catherine Logan

Keywords

intra-articular lisartan

cartilage healing

microfracture

hyaline-like cartilage repair

rabbit model