2021 Annual Meeting Knee Access Pass-Biologic Augmentation with Mesenchymal Stem Cells in Anterior Cruciate Ligament Reconstruction

Biologic Augmentation with Mesenchymal Stem Cells in Anterior Cruciate Ligament Reconstruction

Video Transcription

Video Summary

This randomized study explored the effects of bone marrow aspirate concentrate (BMAC) on ACL allograft remodeling, using T2 MRI signal intensity as a marker for ligamentization. Results showed a significant 50% increase in signal intensity at three months post-injection, suggesting enhanced metabolic activity and remodeling. Additionally, BMAC recipients exhibited improved iKDC scores at nine months, though below clinical significance thresholds. No significant differences were found in physical exams or graft failure rates at one year. The study highlights BMAC's potential to accelerate healing, but calls for further research to clarify mechanisms, dosing effects, and long-term structural outcomes in ACL reconstruction.

Asset Caption

Dr. Brian Forsythe | ACL Graft and Revision

Keywords

Bone Marrow Aspirate Concentrate

ACL Allograft Remodeling

T2 MRI Signal Intensity

Ligamentization

iKDC Scores